2-(4-Methoxyphenyl)-1,1-dimethylethylamine → alpha-(alpha,alpha-Dimethyl-4-methoxyphenethylimino)-2-n-butoxyacetophenone

HRID 1680881Notes

Reaction equation

HRID 1680881 reaction equation
O.C(O[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([CH:15]=[O:16])=[O:14])CCC.[CH3:17][C:18]([NH2:29])([CH3:28])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1>CS(C)=O>[CH3:28][C:18]([N:29]=[C:15]([O:16][CH2:12][CH2:7][CH2:8][CH3:9])[C:13]([C:8]1[CH:7]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:14])([CH3:17])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 918922-(4-Methoxyphenyl)-1,1-dimethylethylamineHCID 204341192-n-Butoxyphenylglyoxal hydrate

Product 1

HCID 23454835alpha-(alpha,alpha-Dimethyl-4-methoxyphenethylimino)-2-n-butoxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent3×

Conditions

Temperature
20 °C

Procedure

632 mg of 2-n-butoxyphenylglyoxal hydrate are dissolved in 0.5 ml of dimethylsulfoxide, and a solution of 440 mg of α,α-dimethyl-4-methoxyphenethylamine in 1.5 ml of dimethylsulfoxide is added thereto. The mixture is stirred at 20° C. for one hour, whereby a solution of α-(α,α-dimethyl-4-methoxyphenethylimino)-2-n-butoxyacetophenone in dimethylsulfoxide is obtained.

Sources & evidence

ORD record
ord-3656c366218f4302a8ae296809742f2f
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

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