Ethanol → HCID 13020601, compound

Participants

Reaction Steps

A mixture of 263 mg of α-[(α,α-dimethyl-3,4-dimethoxyphenethylamino)methyl]-2-benzyloxybenzylalcohol oxalate (M.p. 157°-158° C.), 150 mg of 10% palladium-carbon and 15 ml of 95% aqueous ethanol is shaken at 20° C. in hydrogen gas atmosphere under atmospheric pressure. After the uptake of hydrogen is completed, insoluble materials are removed by filtration. The filtrate is evaporated to remove the solvent. The residue (colorless oil) is crystallized with a mixture of acetone and ether, and then recrystallized from isopropylalcohol. 180 mg of α-[(α,α-dimethyl-3,4-dimethoxyphenethylamino)methyl]-2-hydroxybenzylalcohol 1/2 oxalate are thereby obtained as colorless prisms.

Provenance & Evidence