4-Chlorobenzoic Acid → HCID 14802297, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.1 g (20 mmol) of 8-amino-3-chloro-7-ethylaminoquinoline, 3.1 g (20 mmol) of 4-chlorobenzoic acid and 20 ml of polyphosphoric acid is heated at 120° C. for 1 hour. It is allowed to cool to 90° C., and 100 g of ice are slowly added to the solution. The mixture is then poured into 200 g of ice, and the pH is adjusted to 12 with concentrated sodium hydroxide solution. The precipitate is filtered off with suction, washed thoroughly with hot water, dried at 70° C. under reduced pressure and recrystallized from ethyl acetate.

Provenance & Evidence