Trifluoroacetic acid → HCID 15023103, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.61 g (30 mmol) of 8-amino-3-methyl-7-methylaminoquinoline and 3.02 ml (40 mmol) of trifluoroacetic acid in 40 ml of 4N hydrochloric acid is heated at 95° C. for 2 h. It is then allowed to cool to room temperature and poured into 250 g of ice, the pH is adjusted to 9 with concentrated sodium hydroxide solution, and the precipitate is filtered off with suction. The crude product is dried and recrystallized from ethyl acetate/petroleum ether.

Provenance & Evidence