Methionin AL → HCID 178447960, compound

Participants

Reaction Steps

Metal sodium (0.3 g) was dissolved in anhydrous methanol (100 m(), followed by adding diethyl 2-(trans-4'-propylcyclohexyl)ethylmalonate (3.2 g) and 3,4-difluorobenzamidine hydrochloride (1.9 g) with stirring, reacting the mixture under reflux for 10 hours, thereafter cooling the reaction solution, pouring it in 6N HCl (100 ml) and ice (300 g), filtering off deposited yellow crystals, washing with water and drying crystals to obtain 4,6-dihydroxy-5-[2'-(trans-4"-propylcyclohexyl)ethyl]-2-(3,4-difluorophenyl)pyrimidine (3.5 g).

Provenance & Evidence