Acetic Anhydride → HCID 178467657, compound

HRID 1681015Notes

Reaction equation

HRID 1681015 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([NH2:11])=[O:10])=[N:4][CH:5]=[C:6]([OH:8])[N:7]=1.[C:12]([O:15][C:16](=O)[CH3:17])(=O)[CH3:13]>CO.CN(C)C=O>[CH2:12]([O:15][CH2:16][C:17]1[NH:11][C:9](=[O:10])[C:3]2[C:2](=[N:7][C:6]([OH:8])=[CH:5][N:4]=2)[N:1]=1)[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1785138073-Amino-5-oxo-4,5-dihydropyrazine-2-carboxamide

Product 1

HCID 178467657HCID 178467657, compound

Reagents, catalysts & solvents 1

HCID 21901440N,N-dimethylformamide methanolSolvent

Procedure

Obtained using the procedure described in Example 1, starting with 2.1 g (0.0136 mole) of 3-amino-5-hydroxy-2-pyrazinecarboxamide [prepared according to E. C. Taylor et al., J. Org. Chem. 1975, 40, 2341], 14.0 g (0.068 mole) of triethyl orthoethoxyacetate and 14.0 ml of acetic anhydride. Yld: 1.2 g (40%), m.p. 255°-256° C. (methanol/N,N-dimethylformamide).

Workup

  1. customObtained

Sources & evidence

ORD record
ord-b2ff0ad4906d4939849fb32fc09e138e
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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