反应详情

Obtained using the procedure described in Example 1, starting with 5.0 g (0.0324 mole) of 3-amino-5-hydroxy-2-pyrazinecarboxamide, 29.5 g (0.134 mole) of triethyl orthoacetoxyacetate and 9.5 ml of acetic anhydride. Refluxing time: 1 hour 45 minutes. Yld: 3.8 g (50%), m.p. >300° C. (ethanol/N,N-dimethylformamide).

1. customObtained
2. temperatureRefluxing time
3. custom1 hour 45 minutes