Ethanol → 2-[(2,3-Dichlorophenoxy)methyl]-4(3H)-pteridinone

HRID 1681023Notes

Reaction equation

HRID 1681023 reaction equation
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=2[Cl:21])[N:3]=1.C([OH:24])C>[OH-].[Na+]>[Cl:21][C:15]1[C:16]([Cl:20])=[CH:17][CH:18]=[CH:19][C:14]=1[O:13][CH2:12][C:4]1[NH:3][C:2](=[O:24])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 105198414-Amino-2-[(2,3-dichlorophenoxy)methyl]pteridine

Product 1

HCID 1354395412-[(2,3-Dichlorophenoxy)methyl]-4(3H)-pteridinone

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Obtained using the procedure described in section b of Example 9, starting with 1.0 g (0.0031 mole) of 4-amino-2-[(2,3-dichlorophenoxy)methyl]pteridine in 35 ml of 5% aqueous sodium hydroxide. Heating time: 10 minutes under reflux. Yld: 0.5 g (50%), m.p. 219°-220.5° C. (ethanol).

Workup

  1. customObtained
  2. temperatureHeating time
  3. temperature10 minutes under reflux

Sources & evidence

ORD record
ord-fe1db9d961a94b3e98ef1386991b6cef
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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