Ethanol → 2-Methoxymethoxymethyl-4(3H)-pteridinone

HRID 1681027Notes

Reaction equation

HRID 1681027 reaction equation
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH2:14][O:15][CH3:16])[N:3]=1.C([OH:19])C>[OH-].[Na+]>[CH3:16][O:15][CH2:14][O:13][CH2:12][C:4]1[NH:3][C:2](=[O:19])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 106804924-Amino-2-(methoxymethoxymethyl)pteridine

Product 1

HCID 1354906372-Methoxymethoxymethyl-4(3H)-pteridinone

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Obtained using the procedure described in section d of Example 2, starting with 5.3 g (0.024 mole) of 4-amino-2-(methoxymethoxymethyl)pteridine in 250 ml of 5% aqueous sodium hydroxide. Heating time: 2 hours at 80° C. Yld: 2.2 g (41%), m.p. 161°-163° C. (ethanol).

Workup

  1. customObtained
  2. temperatureHeating time
  3. custom2 hours
  4. customat 80° C

Sources & evidence

ORD record
ord-ddc9770885324102a3b4a32082c0c4f6
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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