HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine | HCID 10539187 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone | HCID 135417224 | — |
Reaction Steps
Obtained using the procedure described in section d of Example 2, starting with 5.0 g (0.0193 mole) of 4-amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine in 105 ml of 5% aqueous sodium hydroxide. Heating time: 1 hour 30 minutes at 80° C. Yld: 2.5 g (50%), m.p. 165°-167° C. (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05167949 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-74ac32f7c06d449cb56b023565d27dc9 |
| Source note | uspto-grants-1992_12 |