HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2-[(4-chlorophenoxy)methyl]pteridine → 2-[(4-Chlorophenoxy)methyl]-4(3H)-pteridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2-[(4-chlorophenoxy)methyl]pteridine | HCID 10755749 | — |
| Reactant | N,N-dimethylformamide ethanol | HCID 19794673 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-[(4-Chlorophenoxy)methyl]-4(3H)-pteridinone | HCID 135496320 | — |
Reaction Steps
Obtained using the procedure described in section b of Example 9, starting with 17.5 g (0.0608 mole) of crude 4-amino-2-[(4-chlorophenoxy)methyl]pteridine in 1750 ml of 5% aqueous sodium hydroxide. Heating time: 1 hours 30 minutes under reflux. Yld: 8.7 g (50%), m.p. 267°-269° C. (ethanol/N,N-dimethylformamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05167949 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-353046d9fabd43b9a4491ac1f3b6244e |
| Source note | uspto-grants-1992_12 |