3-Aminopyrazine-2-carbonitrile → HCID 10850551, compound

HRID 1681042Notes

Reaction equation

HRID 1681042 reaction equation
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH2:10]([S:17][CH2:18][C:19](N)=[NH:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:19]([CH2:18][S:17][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:20]=1

Participants

4

Reactant 2

HCID 8176993-Aminopyrazine-2-carbonitrileHCID 18967941HCID 18967941, compound

Product 1

HCID 10850551HCID 10850551, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 2.3 g (0.019 mole) of 3-amino-2-pyrazinecarbonitrile and 5.2 g (0.029 mole) of 2-(benzylthio)acetamidine [prepared according to J. M. McManus, J. Heterocycl. Chem. 1968, 5, 137] in 150 ml of absolute ethanol is refluxed for 2 hours. After cooling, the solution obtained is concentrated to dryness under reduced pressure. The residue is washed with isopropyl ether and dried under reduced pressure. An amorphous solid is obtained, and is used in the next step without further purification. Yld: 5.4 g (quantitative).

Workup

  1. temperatureis refluxed for 2 hours
  2. temperatureAfter cooling
  3. customthe solution obtained
  4. concentrationis concentrated to dryness under reduced pressure
  5. washThe residue is washed with isopropyl ether
  6. customdried under reduced pressure
  7. customAn amorphous solid is obtained
  8. customis used in the next step without further purification

Sources & evidence

ORD record
ord-0e09b592ba6b45ad943912fdff33a97e
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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