Sodium Hydroxide → HCID 178499629, compound

HRID 1681047Notes

Reaction equation

HRID 1681047 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([O:12]C)=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:14][O:15][CH2:16][O:17][CH3:18])[N:3]=1.[OH-].[Na+]>O>[NH2:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([OH:12])=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:14][O:15][CH2:16][O:17][CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 148801434-Amino-7-methoxy-2-(methoxymethoxymethyl)pteridine

Product 1

HCID 178499629HCID 178499629, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

8.1 g (0.0322 mole) of 4-amino-7-methoxy-2-(methoxymethoxymethyl)pteridine are added to a solution of 3.2 g (0.080 mole) of sodium hydroxide in 130 ml of water. The suspension obtained is heated at 80° C. for 2 hours. After filtration while hot, the solution is allowed to return to room temperature and is then acidified with acetic acid. The precipitate formed is isolated by filtration. It is purified by washing with water and then with acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide. Yld. 4.4 g (58%), m.p. 210°-212° C.

Workup

  1. customThe suspension obtained
  2. filtrationAfter filtration while hot, the solution
  3. customto return to room temperature
  4. customThe precipitate formed
  5. customis isolated by filtration
  6. customIt is purified
  7. washby washing with water
  8. customwith acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide

Sources & evidence

ORD record
ord-9d3a6e3b5a994aefbe8dd9cb98574131
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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