HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 5,6-Diamino-2-(ethoxymethyl)-4(3H)-pyrimidinone hemimaleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | 5,6-diamino-2-(ethoxymethyl)-4(3H)-pyrimidinone | HCID 135749805 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5,6-Diamino-2-(ethoxymethyl)-4(3H)-pyrimidinone hemimaleate | HCID 137225487 | — |
Reaction Steps
A mixture of 3.4 g (0.0185 mole) of 5,6-diamino-2-(ethoxymethyl)-4(3H)-pyrimidinone, 4.4 g (0.0379 mole) of maleic acid, 300 ml of absolute ethanol and 100 ml of methanol is brought to reflux. The small insoluble portion is removed by filtration while hot. After cooling, the precipitate formed is isolated by filtration; it is washed with ethyl ether and recrystallized from absolute ethanol. Yld: 2.0 g (45%) m.p. 192°-194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05167949 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-a77087dc65f644bcb963b5ecef0673b4 |
| Source note | uspto-grants-1992_12 |