Dimethyl Sulfoxide → HCID 19808146, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylsulfoxide (312 mg), oxalyl chloride (254 mg) and triethyl amine (600 mg) were added to the alcohol [prepared in (1)] dissolved in methylene chloride (5 ml). The mixture was stirred for 1 hour at -35° C. Water was added to the reaction mixture. The mixture was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and then evaporated. The residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=7:3) to obtain the title compound (405 mg) having the following physical data.

Provenance & Evidence