Sodium borohydride → HCID 14257858, compound

Participants

Reaction Steps

To a solution of [1-(2-phenylethyl)-4-piperidinyl][3-(trifluoromethyl)-phenyl]-methanone (2.8 g, 7.75 mmol) in methanol (50 ml) cooled in an ice bath was added portionwise sodium borohydride (0.3 g, 7.75 mmol). The reaction was allowed to warm to room temperature and stirred an additional 4 h. The mixture was evaporated and the residue extracted with Et2O, washed with H2O (3×100 ml), saturated aqueous NaCl (1×100 ml), dried (Mg SO4), filtered and evaporated to give a white solid. This solid was recrystallized from ether-hexane to give white needles, mp 143°-147° C.

Provenance & Evidence