Hydroxylamine, O-ethyl- → HCID 136118803, compound

HRID 1681088Notes

Reaction equation

HRID 1681088 reaction equation
[C:1]([CH:6]1[C:11](=[O:12])[CH2:10][CH:9]([CH:13]2[CH2:18][CH2:17][CH:16]3[O:19][CH:15]3[CH2:14]2)[CH2:8][C:7]1=[O:20])(=O)[CH2:2][CH2:3][CH3:4].[CH2:21]([O:23][NH2:24])[CH3:22]>CO>[CH2:21]([O:23][N:24]=[C:1]([C:6]1[C:11](=[O:12])[CH2:10][CH:9]([CH:13]2[CH2:18][CH2:17][CH:16]3[O:19][CH:15]3[CH2:14]2)[CH2:8][C:7]=1[OH:20])[CH2:2][CH2:3][CH3:4])[CH3:22]

Participants

4

Reactant 2

HCID 69357Hydroxylamine, O-ethyl-HCID 13589693HCID 13589693, compound

Product 1

HCID 136118803HCID 136118803, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.5 parts by weight of 2-butyryl-5-(3,4-epoxycyclohexyl)-cyclohexane-1,3-dione and 0.8 part by weight of ethoxyamine in 100 parts by volume of methanol were stirred for 16 hours at room temperature. The solvent was distilled off under reduced pressure, the residue was dissolved in dichloromethane, the solution was washed with 5% strength by weight hydrochloric acid and water and dried over sodium sulfate, and the solvent was distilled off under reduced pressure. 2-(1-Ethoxyiminobutyl)-5-(3,4-epoxycyclohexyl)-3-hydroxycyclohex-2-en-1-one (active ingredient No. 2) was obtained.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. dissolutionthe residue was dissolved in dichloromethane
  3. washthe solution was washed with 5% strength by weight hydrochloric acid and water
  4. dry with materialdried over sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3b8f5d9ed7454ad990a129712ea11e11
Source dataset
uspto-grants-1992_12
Patent number
US05169426

Reaction notes

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