Sodium Hydroxide → HCID 12040848, compound

Participants

Reaction Steps

3-Amino-6-chloro-2-(2-chloro-2-propenyl)-4-fluorophenol (4.8 g) was dissolved in chloroform (20 ml), and trifluoromethanesulfonic acid (4.6 g)was dropwise added thereto at 5° C. for 5 minutes, followed by stirring at room temperature for 5 hours. After completion of the reaction, the reaction mixture was poured into a 5% NaOH solution (30 ml) at 5° C. and extracted with ethyl acetate. The organic layer was dried and concentrated to give 4-amino-7-chloro-5-fluoro-2-methylbenzo[b]furan (3.5 g; yield, 86%).

Provenance & Evidence