Methyl chloroformate → HCID 19806966, compound

Participants

Reaction Steps

A mixture of 4-amino-7-chloro-5-fluoro-2-methylbenzo[b]furan (3.4 g) and N,N-diethylaniline (2.6 g) was dissolved in tetrahydrofuran (20 ml), and methyl chlorocarbonate (1.6 g) was dropwise added thereto at room temperature. The resultant mixture was heated under reflux for 3 hours. After cooling to room temperature, the reaction mixture was dissolved in ethyl acetate and washed with 10% hydrochloric acid. After removal of N,N-diethylaniline, the reaction mixture was dried and concentrated. The residue was washed with hexane to give 7-chloro-5-fluoro-4-methoxycarbonylamino-2-methylbenzo[b]furan (3.8 g; yield, 87%). m.p., 168°-169° C.

Provenance & Evidence