Dimethylformamide dimethyl acetal → N-((Dimethylamino)methylene)-7-phenylpyrazolo(1,5-a)pyrimidine-3-carboxamid

HRID 1681144ノート

反応式

HRID 1681144 の反応式
[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([NH2:18])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>ClCCl>[CH3:21][N:22]([CH:24]=[N:18][C:16]([C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:8][CH:9]=[N:10][C:11]=12)=[O:17])[CH3:23]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 145018607-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

生成物 1

HCID 15042090N-((Dimethylamino)methylene)-7-phenylpyrazolo(1,5-a)pyrimidine-3-carboxamid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 600 mg of 7-phenylpyrazolo(1,5-a)-pyrimidine-3-carboxamide (Example 7), 5.0 ml of N,N-dimethylformamide dimethyl acetal and 25.0 ml of dichloromethane are heated on a steam bath for 2 hours with complete solution taking place. The solution is evaporated in vacuo to give a solid. The solid is then recrystallized from acetone to give 58 mg of the desired product as yellow needles, mp 198°-201.5° C.

後処理

  1. temperatureare heated on a steam bath for 2 hours with complete solution
  2. customThe solution is evaporated in vacuo
  3. customto give a solid
  4. customThe solid is then recrystallized from acetone

出典と根拠

ORDレコード
ord-a42683fa2a964f09b44180a4b62fe23f
出典データセット
uspto-grants-1992_12
特許番号
US05169850

反応ノート

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