(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → (RS)-4-(4-Ethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

HRID 168116Notes

Reaction equation

HRID 168116 reaction equation
[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[O:24][c:25]1[cH:26][cH:27][c:28]2[c:29]([cH:35]1)[CH2:30][CH:31]([CH2:33][Br:34])[O:32]2.[CH2:1]([CH3:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][C:8]2([OH:14])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:15][cH:16]1>>[CH2:1]([CH3:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][C:8]2([OH:14])[CH2:9][CH2:10][N:11]([CH2:33][CH:31]3[CH2:30][c:29]4[c:28]([cH:27][cH:26][c:25]([O:24][CH2:17][c:18]5[cH:19][cH:20][cH:21][cH:22][cH:23]5)[cH:35]4)[O:32]3)[CH2:12][CH2:13]2)[cH:15][cH:16]1

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 226284084-[(4-Ethylphenyl)methyl]piperidin-4-ol

Product 1

HCID 22628361(RS)-4-(4-Ethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-97c904e811f94ababc0dc333ad1d7a9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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