Thionyl Chloride → 2,3,4,5-Tetrafluorobenzoyl chloride

Participants

Reaction Steps

Thionyl chloride (2.9 L), 2.5 kg 2,3,4,5-tetrafluorobenzoic acid and 14.5 ml dimethylformamide were charged to a 12 L reaction vessel and warmed at 90°-95° C. for about 90 minutes. The excess thionyl chloride was first removed at atmospheric pressure, then in vacuo. The residue was distilled on a steam bath at water pump pressure collecting the fraction with b.p. 65°-70° C. at about 15 mm resulting in 2635 g (96.2%) of pale yellow distillate.

Provenance & Evidence