HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylphosphoramide → Ethyl 1-cyclopropyl-6-fluoro-7-[2,6-di(trifluoromethyl)-4-pyridinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2,6-Di(trifluoromethyl)-4-(trimethylstannyl)pyridine | HCID 15030321 | — |
| Reactant | 7-Bromo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate | HCID 19807250 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | Ethyl 1-cyclopropyl-6-fluoro-7-[2,6-di(trifluoromethyl)-4-pyridinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate | HCID 15030322 | — |
Reaction Steps
Ethyl 1-cyclopropyl-6-fluoro-7-[2,6-di(trifluoromethyl)-4-pyridinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate was prepared from 4 g 7-bromo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 5 g 2,6-di(trifluoromethyl)-4-(trimethylstannyl)pyridine, 400 mg dichlorobis(triphenylphosphine)palladium and 2 ml HMPA in 60 ml dioxane according to the procedure of Example 1, part (h), and was obtained (2.8 g) as a solid with m.p. 239°-241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05169853 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-dd9f476194904d81b184b887f82ef57a |
| Source note | uspto-grants-1992_12 |