Hydrochloric Acid → HCID 10386045, compound

Participants

Reaction Steps

Ethanolic hydrogen chloride (150 ml) was added to a suspension of 7.5 g ethyl 7-[2-(acetoxymethyl)-6-methyl-4-pyridinyl]-1-cyclopropyl-6-fluoro-1,4dihydro-4-oxo-3-quinolinecarboxylate (Example 17a) in 200 ml absolute ethanol, and the mixture heated at reflux for 90 min. The reaction mixture was concentrated in vacuo to give 6.68 g ethyl 1-cyclopropyl-6-fluoro-7-[2-(hydroxymethyl)-6-methyl-4-pyridinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylate in the form of its hydrochloride salt, m.p. 240° C.(decompn.).

Provenance & Evidence