4-Chlorophenyl Isocyanate → HCID 19807347, compound

HRID 1681215Notes

Reaction equation

HRID 1681215 reaction equation
[S:1]1[CH:5]=[C:4]([S:6]([NH2:9])(=[O:8])=[O:7])[C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[O:23])=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:9][S:6]([C:4]2[C:3]3[CH:10]=[CH:11][CH:12]=[CH:13][C:2]=3[S:1][CH:5]=2)(=[O:7])=[O:8])=[O:23])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 13178324HCID 13178324, compound

Product 1

HCID 19807347HCID 19807347, compoundYield 46.9%

Procedure

3-Benzo[B]thiophenesulfonamide (6.4 mmol) was reacted with 4-chlorophenylisocyanate (6.4 mmol) as described in Method A to obtain 1.1 g of the title product as a solid. 1H NMR (CD3SOCD3): δ10.94 (bs, 1 H), 8.99 (s, 1 H), 8.75 (s, 1 H), 8.27 (d, J =8 Hz, 1 H), 8.16 (d, J =8 Hz, 1 H), 7.60 (dd, J =8, 8 Hz, 1 H), 7.53 (dd, J =8, 8 Hz, 1 H), 7.38 (d, J =9 Hz, 2 H), 7.31 (d, J =9 Hz, 2 H).

Sources & evidence

ORD record
ord-4ccc7195ce67496891fa3b01e956b95c
Source dataset
uspto-grants-1992_12
Patent number
US05169860

Reaction notes

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