Pyridoxal hydrochloride → HCID 136403410, compound

HRID 1681222Notes

Reaction equation

HRID 1681222 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:9]([OH:10])=[C:8]([CH:11]=O)[C:7]([CH2:13][OH:14])=[CH:6][N:5]=1.[ClH:15].Cl.Cl.[O:18]([CH2:20][CH:21]([F:25])[CH2:22][NH:23][CH3:24])[NH2:19]>C(O)C>[ClH:15].[OH:10][C:9]1[C:4]([CH3:3])=[N:5][CH:6]=[C:7]([CH2:13][OH:14])[C:8]=1[CH:11]=[N:19][O:18][CH2:20][CH:21]([F:25])[CH2:22][NH:23][CH3:24]

Participants

5

Reactant 3

HCID 6171Pyridoxal hydrochlorideHCID 14798Sodium HydroxideHCID 19807375HCID 19807375, compound

Product 1

HCID 136403410HCID 136403410, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.0 ml of 1N sodium hydroxide solution and 408 mg (2 mmol) of pyridoxal hydrochloride are added to a solution of 390 mg (2.0 mmol) of N-(3-aminoxy-2-fluoropropyl)-methylamine dihydrochloride in 10 ml of ethanol and the mixture is stirred for 16 hours at room temperature. The reaction mixture is then concentrated to dryness by evaporation and the title compound is crystallised from ethyl acetate.

Workup

  1. concentrationThe reaction mixture is then concentrated to dryness by evaporation
  2. customthe title compound is crystallised from ethyl acetate

Sources & evidence

ORD record
ord-8e0354722b344f83aa2a645ac9f9640c
Source dataset
uspto-grants-1992_12
Patent number
US05169867

Reaction notes

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