Acetone → HCID 19807367, compound

HRID 1681223Notes

Reaction equation

HRID 1681223 reaction equation
[OH-].[Na+].[CH3:3][C:4]([CH3:6])=O.[ClH:7].Cl.[O:9]([CH2:11][CH:12]([F:16])[CH2:13][NH:14][CH3:15])[NH2:10]>C(O)C>[ClH:7].[C:4](=[N:10][O:9][CH2:11][CH:12]([F:16])[CH2:13][NH:14][CH3:15])([CH3:6])[CH3:3]

Participants

5

Reactant 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 19807375HCID 19807375, compound

Product 1

HCID 19807367HCID 19807367, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.5 ml of 1N sodium hydroxide solution and 0.36 ml (5 mmol) of acetone are added to a solution of 488 mg (2.5 mmol) of N-(3-aminoxy-2-fluropropyl)-methylamine dihydrochloride in 10 ml of ethanol and the mixture is stirred for 24 hours at room temperature. The reaction mixture is then concentrated to dryness by evaporation. The residue is taken up in ethanol, filtered and crystallised by the addition of ether.

Workup

  1. concentrationThe reaction mixture is then concentrated to dryness by evaporation
  2. filtrationfiltered
  3. customcrystallised by the addition of ether

Sources & evidence

ORD record
ord-fff55516d8514398bd9e387326095333
Source dataset
uspto-grants-1992_12
Patent number
US05169867

Reaction notes

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