Potassium Hydroxide → HCID 9834537, compound

Participants

Reaction Conditions

Reaction Steps

5.3 ml (5.3 mmol) of diisobutylaluminum hydride (1M in toluene) are added under nitrogen at -78° C. to 1.35 g (5.2 mmol) of the compound from Example 28 in 25 ml of absolute tetrahydrofuran and, after warming to 25° C., the mixture is hydrolyzed using 20% strength potassium hydroxide solution. The aqueous phase is washed with ethyl acetate and the combined organic phases are dried. After evaporating in vacuo, 1.12 g of crude product are obtained.

Provenance & Evidence