Sodium Bicarbonate → HCID 19807310, compound

Participants

Reaction Steps

2.6 ml (2.6 mmol) of a 1molar tetrabutylammonium fluoride solution in tetrahydrofuran are added to 1.3 g (2.6 mmol) of the compound from Example 65 dissolved in 20 ml of absolute tetrahydrofuran and the mixture is stirred for 1 hour of room temperature. Saturated sodium hydrogen carbonate solution is added to the mixture and it is extracted several times using dichloromethane. The organic phase is dried over magnesium sulphate and concentrated in vacuo, and the residue is chromatographed on a column (silicia gel 70-230 mesh, using ethyl acetate/petroleum ether 1:9) as eluent).

Provenance & Evidence