HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-(Dimethoxymethyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Reactant | Methylorthoformate | HCID 53629101 | — |
| Product | 3-(Dimethoxymethyl)thiophene | HCID 15918138 | — |
Reaction Steps
224 g of 3-thiophenecarbaldehyde and 265 g of methyl orthoformate are dissolved in 200 ml of methanol. One g of strongly acidic ion-exchange resin Amberlite IR-120(H+) [manufactured by Rohm & Haas] is added thereto, and the mixture is refluxed with heating for 2 hours. The resin is separated by filtration, and the filtrate is condensed under reduced pressure. The residue is distilled to give 294 g of 3-dimethoxymethylthiophene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05169861 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-64a9f4300d254effa964258078d15c1f |
| Source note | uspto-grants-1992_12 |