Phenylethanolamine → Diisopropylether methanol

Participants

Reaction Steps

A mixture of trans-stilbene oxide (2.44 g, 0.0125 mol) and 2-amino-1-phenylethanol (5.12 g, 0.0374 mol) was heated on a steam bath for 3 hours and allowed to stand at ambient temperature for 16 hours. Trituration with methanol-isopropyl ether gave a white solid (1.12 g, 77% yield). The solid was recrystallized from methanol-water to obtain 0.8 g of the product, mp 162°-163° C.

Provenance & Evidence