(Tetrahydro-2H-pyran-2-ylmethyl)amine → HCID 19806412, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-stilbene oxide (1.96 g, 0.010 mol) and 2-aminomethyltetrahydropyran (3.45 g, 0.030 mol) was heated in an oil bath at 140° C. for 6 hours. After standing at ambient temperature for 14 hours, the solidified reaction mixture was triturated with isooctane, and the tan solid collected by filtration to obtain 2.59 g (83% yield) of the product. The material was recrystallized from toluene-isooctane; mp 159°-163° C.

Provenance & Evidence