Water → HCID 19806404, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-stilbene oxide (1.96 g, 0.010 mol) and 4-amino-1-benzylpiperidine (5.70 g, 0.030 mol) was heated at 145° C. in an oil bath for 15 hours. The cooled mixture was then dissolved in methanol (20 mL) and the solution poured into water (200 mL). The product separated as an oil that solidified on standing. The solid was collected and dried under ambient conditions for 18 hours to obtain 3.68 g (95%) of material. Recrystallization from toluene-isooctane gave 2.31 g of the product as a tan solid; mp 128°-130° C.

Provenance & Evidence