Ammonia → HCID 10582802, compound

HRID 1681381Notes

Reaction equation

HRID 1681381 reaction equation
O[CH:2]([CH3:10])[CH2:3][NH:4][C:5]([CH3:9])([CH3:8])[CH2:6]O.[NH3:11]>O>[CH3:9][C:5]1([CH3:8])[CH2:6][NH:11][CH:2]([CH3:10])[CH2:3][NH:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19806490HCID 19806490, compound

Product 1

HCID 10582802HCID 10582802, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In this example, a sample of 2,2,5-trimethylpiperazine was prepared by substantially following the procedure set forth in Example II. However, in this example, 120 g of crude N-(2'-hydroxypropyl)-2-amino-2-methyl-1-propanol, 90 g of water, 60 g of a Ni-Cu-Cr catalyst, and 102 g of ammonia were charged. GLC analysis showed that a 48% yield of 2,2,5-trimethylpiperazine was obtained with 55% dialkanolamine conversion.

Sources & evidence

ORD record
ord-92310506ca294beaa8aff87405f672f5
Source dataset
uspto-grants-1992_12
Patent number
US05171819

Reaction notes

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