Hydrochloric Acid → HCID 19806567, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino-3-cyano-5-(4-methylimidazol-1-yl)toluene (166 mg) in tetrahydrofuran (2.6 ml) was added 1.5M diisobutylaluminium hydride (1.1 ml) at 0° C. and the mixture was stirred at 40° C. for 6 hours. After the reaction was completed, 10 ml of 3N hydrogen chloride solution was added to the reaction mixture. The whole mixture was stirred for 1 hour. The mixture was bacidified with saturated sodium bicarbonate solution and was extracted with chloroform. The extract was dried with Na2SO4 and solvent was distilled to give 63 mg (38%) of the title compound.

Provenance & Evidence