2-Methylimidazole → HCID 13810557, compound

HRID 1681403Notes

Reaction equation

HRID 1681403 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=1)=O.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>>[C:14]([NH:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[C:20]3[N:19]([C:18]([CH3:17])=[N:22][CH:21]=3)[CH2:2][CH2:3][CH:4]=2)=[CH:8][CH:9]=1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 13091617N-[4-(4-Chlorobutanoyl)phenyl]acetamide

Product 1

HCID 13810557HCID 13810557, compound

Procedure

Combine 20 g (83.4 mmol) of N-[4-(4-chloro-1-oxobutan-1-yl)phenyl]acetamide with 50 g (0.61 mol) of 2-methylimidazole and heat to 175° C. for 18 hr. Crystallization from ethyl acetate provides the title compound.

Workup

  1. customCrystallization from ethyl acetate

Sources & evidence

ORD record
ord-edeec1364a0b4ec090cf19b9f9ade90e
Source dataset
uspto-grants-1992_12
Patent number
US05171858

Reaction notes

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