2-Methylimidazole → HCID 13764014, compound

HRID 1681426Notes

Reaction equation

HRID 1681426 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH:16]=[CH:15][N:14]=[CH:13]3)=[CH:8][CH:7]=2)=O)[CH2:3][CH2:2]1.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>>[N:12]1([C:9]2[CH:8]=[CH:7][C:6]([C:4]3[C:20]4[N:19]([C:18]([CH3:17])=[N:22][CH:21]=4)[CH2:2][CH2:3][CH:1]=3)=[CH:11][CH:10]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 13764011HCID 13764011, compound

Product 1

HCID 13764014HCID 13764014, compound

Procedure

Combine 100 g (0.47 mol) of cyclopropyl-[4-(1H-imidazol-1-yl)phenyl]methanone with 300 g (3.7 mol) of 2-methylimidazole and heat to 175° C. under argon for 14 hr. Crystallization from acetonitrile provides the title compound.

Workup

  1. customCrystallization from acetonitrile

Sources & evidence

ORD record
ord-376b56c6cf6e4246a8ab6e8cbd272aeb
Source dataset
uspto-grants-1992_12
Patent number
US05171859

Reaction notes

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