4-Chlorophenyl cyclopropyl ketone → HCID 13764025, compound

HRID 1681429Notes

Reaction equation

HRID 1681429 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)=O)[CH2:3][CH2:2]1.[CH2:13]([C:15]1[NH:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[CH3:14]>>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([C:4]2[C:1]3[N:16]([C:15]([CH2:13][CH3:14])=[N:19][C:3]=3[CH3:2])[CH2:17][CH2:18][CH:20]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 811484-Chlorophenyl cyclopropyl ketoneHCID 178437635HCID 178437635, compound

Product 1

HCID 13764025HCID 13764025, compound

Procedure

Combine 25 g (0.14 mol) of 4-chlorophenyl cyclopropyl ketone with 50 g (0.45 mol) of 2-ethyl-4-methylimidazole, and heat to 175° C. under argon for 40 hr. Isolate the title compound by column chromatography on 500 g of silica gel using 1% methanol/methylene chloride as solvent.

Sources & evidence

ORD record
ord-6ea2cba266e14c1bb3a538f6e3fabdb5
Source dataset
uspto-grants-1992_12
Patent number
US05171859

Reaction notes

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