HCID 15671289, compound → HCID 14555261, compound

Participants

Reaction Steps

Raney nickel (100 mg) was added to a solution of (-)-N-[(R)-α-methylbenzyl]-6-fluoro-4-oxo-4H-1-benzopyran-2-carboxamide (1.00 g, 3.21 mmol, obtained in Example 9 or 10) in ethanol (20 ml) and the mixture was hydrogenated for 1 hour at a temperature of 55°-60° C. under H2 atomosphere (1 kg/cm2) with stirring. It was determined that the (+)-isomer/(-)-isomer ratio of the reduction product was 1.4/1 (26% d.e.) by 1H-NMR analysis.

Provenance & Evidence