HCID 54314069, compound → HCID 54419805, compound

Participants

Reaction Steps

Raney nickel (400 mg) was added to a solution of (-)-N-[(R)-α-methyl-p-chlorobenzyl]-6-fluoro-4-oxo-4H-1-benzopyran-2-carboxamide (1.00 g, 2.89 mmol, obtained in Example 7) in ethanol (20 ml) and the mixture was hydrogenated for 5 hour at a temperature of 55°-60° C. under H2 atomosphere (4 kg/cm2) with stirring. It was determined that the (+)-isomer/(-)-isomer ratio of the reduction product was 2.7/1 (46% d.e.) by 1H-NMR analysis.

Provenance & Evidence