HCID 19806735, compound → HCID 19806657, compound

Participants

Reaction Steps

3-Ethoxy-4-bromo-5-carbamoylisothiazole (2.51 g, 0.01 mol) was dissolved in 20 ml of trifluoroacetic acid and the solution cooled to 0° to 5° C. Sodium nitrite (2.76 o, 0.04 mol) was added in small portions to the stirred solution over a five minute period. Stirring was continued for 10 minutes at the same temperature and the reaction mixture poured into 150 ml of ice water. The title compound separated as a white solid (2.2 g, 88%, mp 151°-152.5° C.) and was filtered, washed with ice water and dried.

Provenance & Evidence