Hexamethyldisilazane → HCID 19806769, compound

Participants

Reaction Steps

To 3-ethoxy-4-bromo-5-t-butyloxycarbonylisothiazole-1,1-dioxide (340 mg, 1.0 mmol) in 5 ml of dry acetonitrile was added hexamethyldisilazane (242 mg, 1.5 mmol) and the solution was stirred at reflux for 7 hours. The reaction mixture was evaporated in vacuo and the residue was refluxed in 10 ml of ethanol for 3/4 hr. Removal of the ethanol in vacuo gave a crude oil which was chromatographed on silica gel. The product was recovered as a viscous yellow oil (210 mg). Trituration in petroleum ether gave a yellow solid, m.p. 128°-130° C. Mass spectral analysis confirmed the structure.

Provenance & Evidence