Methanol → HCID 19806764, compound

HRID 1681475Notes

Reaction equation

HRID 1681475 reaction equation
CS([C:5]1[C:9](S(C)(=O)=O)=[C:8]([C:14]#[N:15])[S:7][N:6]=1)(=O)=O.[C:16](=[O:19])([O-])[O-].[Na+].[Na+].[OH2:22].[CH3:23]O>>[CH3:23][O:22][C:5]1[C:9]([O:19][CH3:16])=[C:8]([C:14]#[N:15])[S:7][N:6]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 962WaterHCID 10340Sodium CarbonateHCID 19806783HCID 19806783, compound

Product 1

HCID 19806764HCID 19806764, compound

Procedure

A mixture of the compound of Example 35 (3.95 g, 0.015 mol) and sodium carbonate (1.58 g, 0.015 mole) in 40 ml methanol can be stirred at reflux for 6 hours. On cooling, the mixture can be poured into water and the precipitate collected by suction filtration. Recrystallization of the solid from ethanol can give the pure title compound.

Workup

  1. temperatureat reflux for 6 hours
  2. temperatureOn cooling
  3. filtrationthe precipitate collected by suction filtration
  4. customRecrystallization of the solid from ethanol

Sources & evidence

ORD record
ord-cda145a2e6c44cdd8ac697eec231d320
Source dataset
uspto-grants-1992_12
Patent number
US05171860

Reaction notes

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