5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178483225, compound

Participants

Reaction Steps

To a solution of 2-[(5-dimethylaminomethyl-2furanyl)methylthio]ethylamine (0.66 g, 3.08 mmol) in acetonitrile (5 ml) under a nitrogen atmosphere there was added solid 3-ethoxy-4-amino-5-methylsulfonylisothiazole-1,1-dioxide (0.77 g, 3.01 mmol) to give an immediate solution and exothermic reaction. After 1/4 hour, the product began to crystallize and after stirring for 15 hours, was collected by filtration (1.2 g). The title compound was recrystallized by dissolving in hot methanol and diluting with several volumes of ether (1.0 g), mp 187°-189°.

Provenance & Evidence