Potassium Hydroxide → HCID 67896895, compound

HRID 1681481Notes

Reaction equation

HRID 1681481 reaction equation
[CH2:1]([O:3][C:4]1[C:8]([Br:9])=[C:7]([C:10]([OH:12])=[O:11])[S:6][N:5]=1)[CH3:2].[OH-].[K+:14]>CO>[K+:14].[Br:9][C:8]1[C:4]([O:3][CH2:1][CH3:2])=[N:5][S:6][C:7]=1[C:10]([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19806657HCID 19806657, compound

Product 1

HCID 67896895HCID 67896895, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 3-ethoxy-4-bromoisothiazole-5-carboxylic acid (2.02 g, 0.0080 mol) in methanol (8 ml) there was added a solution of potassium hydroxide (0.45 g, 0.0080 mol) in methanol (8 ml). The resulting solution was stirred at ambient temperature for 10 minutes and concentrated to dryness in vacuo. The residue was dried (60°, 0.1 mm) to give 4-bromo-3-ethoxyisothiazole-5-carboxylic acid potassium salt (2.24 g, 97%, mp 265°-268° (d)).

Workup

  1. concentrationconcentrated to dryness in vacuo
  2. customThe residue was dried (60°, 0.1 mm)

Sources & evidence

ORD record
ord-cf2d496c364e402d8e5ababf61d2c8f6
Source dataset
uspto-grants-1992_12
Patent number
US05171860

Reaction notes

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