反应详情

Add 6.0 g (0.03 moles) 4-chloro-3-nitrobenzamide to 60 ml 2-aminoethanol and stir at ambient temperature. When TLC (silica support; 9:1 CHCL3 :MeOH eluent) shows no starting material, ca. 3 hrs., pour onto ice. Filter, wash (3×15 ml) with cold H2O, and recrystallize from MeOH/IPA. Yield is 4.5 g (66%) of orange crystals.

1. customno starting material, ca. 3 hrs
2. addition, pour onto ice
3. filtrationFilter
4. washwash (3×15 ml) with cold H2O
5. customrecrystallize from MeOH/IPA