Methyl 3-(5-trimethylsilyl-3-furyl)propionate → 3-(2-Trimethylsilyl-4-furyl)propan-1-ol

HRID 1681510노트

반응식

HRID 1681510 반응식
[CH3:1][Si:2]([CH3:15])([CH3:14])[C:3]1[O:4][CH:5]=[C:6]([CH2:8][CH2:9][C:10](OC)=[O:11])[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:15][Si:2]([CH3:1])([CH3:14])[C:3]1[O:4][CH:5]=[C:6]([CH2:8][CH2:9][CH2:10][OH:11])[CH:7]=1

참가 물질

4

반응물 2

HCID 19019871Methyl 3-(5-trimethylsilyl-3-furyl)propionateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 150370913-(2-Trimethylsilyl-4-furyl)propan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of methyl 3-(2-trimethylsilyl-4-furyl)-propionate (from above) in tetrahydrofuran (3 ml) was added dropwise to a suspension of lithium aluminum hydride (27 mg) in tetrahydrofuran (4 ml) at room temperature. After 3 hours, the mixture was quenched with ethyl acetate and extracted with ether. Evaporation of the dried (magnesium sulphate) extracts gave the title alcohol, which was used in the next step without purification.

후처리

  1. customthe mixture was quenched with ethyl acetate
  2. extractionextracted with ether
  3. customEvaporation of the
  4. dry with materialdried (magnesium sulphate)

출처 및 근거

ORD 기록
ord-dcb38ec11f69401cbd2ef767bb9df1f3
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05171863

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