HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ibuprofen, (+-)- → beta-Methyl-4-(2-methylpropyl)benzeneethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ibuprofen, (+-)- | HCID 3672 | — |
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | Isobutylbenzene | HCID 10870 | — |
| Product | beta-Methyl-4-(2-methylpropyl)benzeneethanol | HCID 595160 | — |
Reaction Steps
preparation of the pharmaceutically-active compound 2-(4-isobutylphenyl) propionic acid, i.e. ibuprofen, by reacting isobutylbenzene with propylene oxide to provide the intermediate 2-(4-isobutylphenyl) propanol followed by oxidation of the alcohol to the corresponding carboxylic acid;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05173281 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-ae77a3e2767349ae8d5e766a733b3c77 |
| Source note | uspto-grants-1992_12 |