Water → HCID 14967721, compound

Participants

Reaction Steps

To 3.1 g of lithium aluminium hydride suspended in 30 ml of tetrahydrofuran there are added 18 g of (5,6-dimethoxyindan-1-yl)carboxylic acid [described in J. Pharm. Sci. (1968) 57 (6) 1013] dissolved in 180 ml of tetrahydrofuran. After stirring at room temperature for 18 hours, there are added dropwise, with cooling, 2.2 ml of water, then 1.7 ml of 20% sodium hydroxide, and finally 7.6 ml of water. The mineral salts are then filtered and rinsed, and the filtrate is evaporated to dryness. In this manner, 16.5 g of (5,6-dimethoxyindan-1-yl)methanol are obtained in the form of an oil, in a yield of 98%.

Provenance & Evidence