Ethylamine → 1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine

HRID 1681590Notes

Reaction equation

HRID 1681590 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([NH2:17])[CH3:16]>>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][NH:17][CH2:15][CH3:16])([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 145784521-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine

Procedure

10.2 g (53.9 mmol) of 5-benzyl-5-aza-1-oxaspiro[2,4]heptane are added dropwise to 60 ml of aqueous ethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.

Workup

  1. concentrationThe batch is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-61355cb3def8458b9969ee0f10103072
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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